Detalhe da pesquisa
1.
Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.
Nat Immunol
; 21(2): 145-157, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31932810
2.
The FAM13A Long Isoform Regulates Cilia Movement and Co-ordination in Airway Mucociliary Transport.
Am J Respir Cell Mol Biol
; 2024 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38691660
3.
Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.
Am J Respir Cell Mol Biol
; 65(5): 544-554, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34181859
4.
PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.
BMC Immunol
; 22(1): 78, 2021 12 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34920698
5.
Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages.
Biophys J
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Artigo
Inglês
| MEDLINE | ID: mdl-33217385
6.
Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.
Drug Metab Dispos
; 48(4): 307-316, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32009006
7.
Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD.
Thorax
; 74(7): 659-666, 2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30674586
8.
Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor.
J Pharmacol Exp Ther
; 369(3): 443-453, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30940692
9.
An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.
Drug Metab Dispos
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Artigo
Inglês
| MEDLINE | ID: mdl-31649125
10.
Airway host-microbiome interactions in chronic obstructive pulmonary disease.
Respir Res
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Artigo
Inglês
| MEDLINE | ID: mdl-31170986
11.
A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma.
J Pharmacol Exp Ther
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Artigo
Inglês
| MEDLINE | ID: mdl-30217958
12.
An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells.
Clin Exp Pharmacol Physiol
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Artigo
Inglês
| MEDLINE | ID: mdl-28508433
13.
Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.
Am J Respir Crit Care Med
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Artigo
Inglês
| MEDLINE | ID: mdl-27064380
14.
Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome.
Lancet
; 385 Suppl 1: S55, 2015 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-26312877
15.
Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model.
Pharm Res
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Inglês
| MEDLINE | ID: mdl-27401409
16.
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.
Eur Respir J
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Artigo
Inglês
| MEDLINE | ID: mdl-32060058
17.
A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice.
Thorax
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Artigo
Inglês
| MEDLINE | ID: mdl-24464743
18.
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.
Nat Med
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Artigo
Inglês
| MEDLINE | ID: mdl-17479101
19.
Histamine-secreting microbes are increased in the gut of adult asthma patients.
J Allergy Clin Immunol
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Artigo
Inglês
| MEDLINE | ID: mdl-27576125
20.
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Clin Pharmacokinet
; 61(2): 281-293, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34458976